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June 21, 2026Respiration

Intrapleural Fibrinolytics use in Children with Pleural Empyema: Safe and Effective

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Authors

CJCarmen C.M. de JongIHIlia E. HeijtingPMPeter Merkus

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Overview

Randomized trial assesses intrapleural fibrinolytics efficacy in children with pleural empyema, implying a less invasive approach.

Key Points

  • The study aims to evaluate the effectiveness and safety of intrapleural fibrinolytics in avoiding video-assisted thoracoscopy (VATS) in children with pleural empyema.
  • Included children referred for chest drainage of pleural effusion from 01-2022 to 04-2023
  • Evaluated symptoms, imaging results, and treatment outcomes
  • Analyzed the effect of intrapleural fibrinolytics on persistent pleural effusion cases.
  • 33 children aged 0-16 years were treated for pleural effusion, with 72% showing fever, cough, and dyspnea
  • 14 (52%) of 27 children with chest drains received intrapleural fibrinolytics, avoiding VATS in most cases
  • No side effects from treatment were observed and overall treatment appears effective.

Cite This Study

Jong et al. (2026) studied this question.

synapsesocial.com/papers/6a3781db24f042ddf4c5b78dhttps://doi.org/10.1159/000553095
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Video-Assisted Thoracoscopic Surgery Versus Tube Thoracostomy with Fibrinolytics for Treatment of Empyema in Children: A Meta-Analysis of Randomized Controlled Studies2025 · 4 citations
  2. 2Clinical Spectrum and Outcome in Children Presenting with Empyema Thoracis in Tertiary Care Hospital: Role of Intrapleural Streptokinase2025
  3. 3Management of parapneumonial pleural empyema in children: a survey of the Italian Society of Infantile Videosurgery (SIVI)2025
  4. 4Use of Intrapleural Alteplase in the Treatment of Parapneumonic Effusion in Children: A Report of a 10-year Experience2025
  5. 5A Multicenter Analysis of Factors Predicting Treatment Success for Intrapleural Enzyme Therapy for Pleural Infection2025