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November 30, 2025Journal of Bronchology & Interventional Pulmonology

A Multicenter Analysis of Factors Predicting Treatment Success for Intrapleural Enzyme Therapy for Pleural Infection

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Authors

LBLeela Krishna Teja BoppanaJFJason FerreiraMMManuel Menendez

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Overview

Retrospective analysis identifies that a community source of infection may improve clinical outcomes for empyema and complicated parapneumonic effusion.

Key Points

  • Successful treatments show a link to a community source of infection, while hospital sources increase the risk of failure.
  • The analysis included 185 patients, with a significant treatment success linked to the type of infection source detected.
  • The retrospective study utilized clinical and radiologic evaluations to assess improvements post-treatment.
  • Determining predictors of success highlights the need for targeted management strategies in empyema and complicated conditions.

Cite This Study

Boppana et al. (2025) studied this question.

synapsesocial.com/papers/692b94341d383f2b2a37871dhttps://doi.org/10.1097/lbr.0000000000001035
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Also Consider

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  1. 1Outperformed by enzymes: why saline lavage falls short of intrapleural enzyme therapy in pleural infection2026
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  3. 3Clinical Spectrum and Outcome in Children Presenting with Empyema Thoracis in Tertiary Care Hospital: Role of Intrapleural Streptokinase2025
  4. 4Intrapleural Fibrinolytics use in Children with Pleural Empyema: Safe and Effective2026
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