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June 20, 2026LeukemiaOpen Access

Comprehensive molecular characterization of treatment-free remission and molecular relapse in chronic myeloid leukemia patients: the EURO-SKI Biomarker Study

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Authors

SRSébastien RinaldettiMCMaryna ChepelevaAHA. Hedblom

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Overview

Randomized trial investigates molecular mechanisms of treatment-free remission in chronic myeloid leukemia, suggesting new therapeutic approaches.

Key Points

  • This research aims to understand the molecular mechanisms behind sustained treatment-free remission and relapse in chronic myeloid leukemia patients.
  • Conducted whole transcriptome gene expression analyses with NanoString nCounter in 240 CML patients and 10 healthy controls.
  • Incorporated transcriptomic data from an external dataset of 96 TKI-naïve CML patients.
  • Analyzed gene expression at the final day of TKI intake for training and validation samples.
  • TFR patients exhibited activation of GATA1, KLF1, and MYBL1 regulons associated with erythroid progenitor cells.
  • Communication between innate and adaptive immunity was maintained in TFR patients, unlike those who lost TFR.
  • Identified an FLT3 threshold that significantly differentiated two groups regarding TFR loss risk.

Cite This Study

Rinaldetti et al. (2026) studied this question.

synapsesocial.com/papers/6a362ee4db0793dc1a536818https://doi.org/10.1038/s41375-026-03001-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gene expression analysis of patients with chronic myeloid leukemia who discontinued tyrosine kinase inhibitor2025
  2. 2TKI Use and Treatment-Free Remission in Chronic Myeloid Leukemia: Evidence from a Regional Cohort Study in the Canary Islands2025
  3. 3Real-World Evidence-Based Study on Treatment-Free Remission in Chronic Myeloid Leukemia2026
  4. 4Clinical and biological predictors of treatment-free remission in CML2025
  5. 5Clinical Features and T‐Cell Repertoire of Chronic Myeloid Leukemia Patients Who Attempt Discontinuation of Tyrosine Kinase Inhibitors: The <scp>ISAC</scp>‐<scp>TFR</scp> Study2025 · 2 citations