What question did this study set out to answer?

The aim is to explore whether genetic differences contribute to observed racial disparities in multiple myeloma risk.

Genomic features do not account for differences in multiple myeloma risk by ancestry

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Randomized trial investigates genomic drivers affecting multiple myeloma risk in different ancestry groups, suggesting no significant disparities.

The aim is to explore whether genetic differences contribute to observed racial disparities in multiple myeloma risk.
Combined whole-genome sequencing data with publicly available datasets (n=1,286)
Investigated germline and somatic genomic features related to multiple myeloma
Analyzed epidemiological data and mutational signatures for comparison between ancestry groups.
No significant differences in germline or somatic genomic features that affect multiple myeloma risk between AFR and EUR populations.
Observed differences in detectability and timing of APOBEC-associated mutations but no clear link to age at diagnosis.
Patients from both AFR and EUR groups show equivalent clinical outcomes with proper access to therapies.

Maclachlan et al. (2026) studied this question.

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Randomized trial investigates genomic drivers affecting multiple myeloma risk in different ancestry groups, suggesting no significant disparities.