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June 13, 2026Nutrition & MetabolismOpen Access

The association between vitamin D and hypothyroidism: a systematic review and meta-analysis

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Authors

XSXiaopeng SunCKChanggui KouY(Yuan Feng (213823)

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Overview

Systematic review demonstrates vitamin D supplementation reduces TSH in individuals with hypothyroidism, suggesting clinical significance.

Key Points

  • This review aimed to assess the effects of vitamin D on hypothyroidism by analyzing available evidence.
  • Conducted systematic review and meta-analysis following PRISMA 2020 guidelines.
  • Analyzed data from 5 randomized controlled trials and 11 observational studies with a total of 4,152 subjects.
  • Used standard mean differences and odds ratios to evaluate the impact of vitamin D on thyroid function and assessed publication bias.
  • Vitamin D supplementation significantly reduced thyroid-stimulating hormone (TSH) levels (SMD = -1.76 mIU L−1, 95% CI [-3.23, -0.29]).
  • Vitamin D supplementation significantly lowered thyroid peroxidase antibody (TPO-Ab) levels (SMD = -113.31 U ml−1, 95% CI [-141.42, -85.21]).
  • Serum vitamin D deficiency was associated with increased odds of hypothyroidism (OR = 4.06, 95% CI [1.96, 8.39]).

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f0562ddhttps://doi.org/10.1186/s12986-026-01157-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of Vitamin D3 as a diagnostic marker in hypothyroidism2025
  2. 2Assessing the correlation between vitamin D deficiency and hypothyroidism2025
  3. 3Vitamin D deficiency in Hashimoto’s thyroiditis: mechanisms, immune modulation, and therapeutic implications2025
  4. 4Normocalcemia and Normal Thyroid Function in a Severe Vitamin D–Deficient Population2025
  5. 5Vitamin D deficiency as a potential risk factor for thyroid cancer: a clinical perspective2025