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September 10, 2025Frontiers in EndocrinologyOpen Access

Vitamin D deficiency in Hashimoto’s thyroiditis: mechanisms, immune modulation, and therapeutic implications

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Authors

WSWencong SunDCDing ChaoYWYichen Wang

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Overview

Review evaluates vitamin D supplementation's effect on immune modulation in Hashimoto's thyroiditis, implying novel treatment protocols.

Key Points

  • Vitamin D deficiency elevates anti-TPO titers by 40–60%, increasing the risk of hypothyroidism.
  • Supplementation of vitamin D at 2000–4000 IU/day can reduce antibodies by 15–30% in deficient euthyroid patients.
  • Preoperative optimization of vitamin D levels lowers hypocalcemia risk by 50% after thyroid surgery.
  • Genotype-guided dosing shows that certain carriers may require lower doses for effective treatment.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d64794ef4https://doi.org/10.3389/fendo.2025.1576850
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vitamin D Receptor Polymorphisms and Immunological Effects of Vitamin D in Hashimoto’s Thyroiditis2025
  2. 2Correlation between Vitamin D levels and thyroid autoantibodies in newly diagnosed Hashimoto’s thyroiditis patients2025
  3. 3The association between vitamin D and hypothyroidism: a systematic review and meta-analysis2026
  4. 4Vitamin D deficiency as a potential risk factor for thyroid cancer: a clinical perspective2025
  5. 5Assessing the correlation between vitamin D deficiency and hypothyroidism2025