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June 12, 2026European Journal of Preventive CardiologyOpen Access

Post-rehabilitation, significant improvements were observed in 6MWT (444.6 to 541.8 m, p<0.001) and bilateral grip strength (p<0.001), with muscle strength moderately correlating with VO2 peak (r=0.4, p<0.001).

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Why the study?

Does a phase II cardiac rehabilitation program improve muscle strength and functional capacity in patients with cardiovascular disease?

Population

446 patients enrolled in a phase II cardiac rehabilitation program, mean age 61.1 ± 11.4 years, 80% men. Key…

Design

Cohort

Authors

NMN MadrugaDCD Inacio CazeiroMRM Reis

Discussion

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Overview

Supports muscle strength assessment in cardiac rehab; hypothesis-generating, requiring RCTs before practice change.

Key Points

  • To explore muscle strength evolution and its correlation with functional capacity during cardiac rehabilitation.
  • Prospective, single-center observational study from 2016 to 2024
  • Included standardized assessments: 6MWT, IPAQ, TUG, FICSIT, and CPET data
  • Statistical analyses with Pearson correlation and pre- and post-program comparisons.
  • 446 patients, mean age 61.1 years, showed significant improvements in functional metrics post-rehabilitation: 6MWT increased from 444.6 to 541.8 m (p<0.001)
  • Moderate correlations found between muscle strength and CPET exercise duration (r=0.4–0.5, p<0.001) and VO2 peak (r=0.4, p<0.001)
  • Patients with VO2 < 18 mL/kg/min had significantly lower functional measures compared to those with VO2 ≥ 18 mL/kg/min.

Structured PICO

Does a phase II cardiac rehabilitation program improve muscle strength and functional capacity in patients with cardiovascular disease?

P
Population
446 patients enrolled in a phase II cardiac rehabilitation program, mean age 61.1 ± 11.4 years, 80% men. Key etiology: ischemic cardiomyopathy (85.2%).
I
Intervention
Phase II cardiac rehabilitation program
O
Outcome
Evolution of muscle strength and correlation with functional capacity assessed by cardiopulmonary exercise testing (CPET) and other functional measuressurrogate

Phase II cardiac rehabilitation significantly improves muscle strength and functional capacity, with muscle strength moderately correlating with peak oxygen uptake.

Cite This Study

Madruga et al. (2026) studied this question.

synapsesocial.com/papers/6a2bd1386550ea4541ffe98ehttps://doi.org/10.1093/eurjpc/zwag249.349
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of the effectiveness of a muscle strengthening protocol as a complement to rehabilitation training in patients with heart failure2026
  2. 2Comparative effects of different strength training modalities in cardiac rehabilitation: preliminary results2026
  3. 3Influence of cardiovascular risk factor count on functional capacity gains in elderly patients undergoing phase 2 cardiac rehabilitation2026
  4. 4Stronger start : dual-mode training boost functional outcome in early phase 2 cardiac rehabilitation after heart valve surgery2026
  5. 5From surviving to thriving: long-term benefits of phase III cardiac rehabilitation2026