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June 12, 2026European Journal of Preventive CardiologyOpen Access

Combined aerobic and resistance training significantly improved 6-minute walk distance (466.39 vs 440.12 m, p=0.013) and 5-sit-to-stand time compared to aerobic training alone post-valve surgery.

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Why the study?

Does early phase 2 cardiac rehabilitation with combined aerobic and resistance training improve functional outcomes in patients post-open heart valve surgery compared to aerobic training alone?

Population

89 patients (2 weeks to 1 month post-surgery) post-open heart valve surgery

Comparison

Supervised combined aerobic and resistance… vs Aerobic training alone

Design

RCT, Randomized

Follow-up

4 weeks

Key result

Combined aerobic and resistance training significantly improved 6-minute walk distance (466.39 vs 440.12 m, p=0.013) and 5-sit-to-stand time compared to aerobic training alone post-valve surgery.

Authors

TST W SiagianERE RamandikaAAA M Ambari

Discussion

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Overview

Supports adding resistance training to aerobic rehab post-valve surgery; extends RCT evidence for multimodal protocols in cardiac recovery.

Key Points

  • Evaluate the impact of combined aerobic and resistance training on functional outcomes in patients post-open heart valve surgery.
  • Prospective randomized controlled trial with 89 patients (2 weeks to 1 month post-surgery)
  • Intervention group (n=46) received combined aerobic and resistance training for 4 weeks; control group (n=43) received aerobic training alone
  • Primary endpoints included Six-Minute Walk Test (6MWT), Five Sit-to-Stand Test (5STS), handgrip strength, and quality of life.
  • Intervention group outperformed control in 6MWT (466.39 m vs. 440.12 m, p=0.013) and 5STS (7.56 s vs. 9.20 s, p<0.001) post-intervention.
  • Significant improvements within both groups for all measures (p<0.001), with greater gains in intervention group for 6MWT (+87.91 m) and 5STS (+3.42 s).
  • No significant between-group differences for handgrip strength (p=0.179) or quality of life (p=0.375).

Study Design

Type

RCT (n=89)

Structured PICO

Does early phase 2 cardiac rehabilitation with combined aerobic and resistance training improve functional outcomes in patients post-open heart valve surgery compared to aerobic training alone?

P
Population
89 patients 2 weeks to 1 month post-open heart valve surgery undergoing early phase 2 cardiac rehabilitation for 4 weeks.
I
Intervention
Supervised combined aerobic and resistance training for 4 weeks (12 sessions)
C
Comparator
Aerobic training alone
O
Outcome
Six-Minute Walk Test (6MWT), Five Sit-to-Stand Test (5STS), handgrip strength, and quality of life assessed by the Kansas City Cardiomyopathy Questionnaire (KCCQ)surrogate

Main Result

Absolute Event Rate: 466.39% vs 440.12%

p-value: p=0.013

Combined aerobic and resistance training in early phase 2 cardiac rehabilitation significantly improves functional capacity compared to aerobic training alone in patients recovering from heart valve surgery.

Cite This Study

Siagian et al. (2026) conducted an RCT in post-open heart valve surgery (n=89). Combined aerobic and resistance training vs. Aerobic training alone was evaluated on Six-Minute Walk Test (6MWT) (p=0.013). Combined aerobic and resistance training significantly improved 6-minute walk distance (466.39 vs 440.12 m, p=0.013) and 5-sit-to-stand time compared to aerobic training alone post-valve surgery.

synapsesocial.com/papers/6a2bd11d6550ea4541ffe8fbhttps://doi.org/10.1093/eurjpc/zwag249.339
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