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June 12, 2026Journal of Cardiovascular ImagingOpen Access

Feature-tracking cardiac magnetic resonance and 2D speckle-tracking echocardiography showed a strong global longitudinal strain correlation (r = 0.793), but limits of agreement spanned 8.3 percentage points, sufficient to misclassify individual patients.

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Population

55 stable patients with chronic ischemic heart disease and reduced ejection fraction

Comparison

Feature-tracking cardiac magnetic resonance vs 2D speckle-tracking echocardiography (2D-STE)

Design

Editorial

Key result

Feature-tracking cardiac magnetic resonance and 2D speckle-tracking echocardiography showed a strong global longitudinal strain correlation (r = 0.793), but limits of agreement spanned 8.3 percentage points, sufficient to misclassify individual patients.

Authors

MMMaajid Mohi Ud Din MalikRJRajesh Prasad Jayaswal

Discussion

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Member takes

Overview

Caution against GLS for individual classification due to wide limits of agreement; leaves open utility pending larger validation.

Key Points

  • This analysis clarifies the methodological points regarding segmental strain comparison in chronic ischemic cardiomyopathy.
  • Intermodality comparison of left ventricular longitudinal strain using FT-CMR and 2D-STE in 55 patients with chronic ischemic heart disease.
  • Statistical analysis included Bonferroni adjustment for 17 segment-level comparisons and limits of agreement calculations.
  • GLS correlation of r = 0.793, P < 0.001 demonstrates strong agreement between modalities.
  • After Bonferroni adjustment, 11 of 17 segmental differences remained significant, indicating robustness of segmental signal.
  • GLS limits of agreement indicate a span of 8.3 percentage points, which may misclassify individual patients.

Structured PICO

P
Population
55 stable patients with chronic ischemic heart disease and reduced ejection fraction undergoing intermodality comparison of left ventricular longitudinal strain.
E
Exposure
Feature-tracking cardiac magnetic resonance (FT-CMR)
C
Comparator
2D speckle-tracking echocardiography (2D-STE)
O
Outcome
Intermodality agreement of left ventricular longitudinal strain (global and segmental)surrogate

Main Result

Effect estimate: r = 0.793

p-value: p=<0.001

Reanalysis of segmental strain data confirms statistical robustness of intermodality differences, but wide limits of agreement between FT-CMR and 2D-STE mean the modalities are not interchangeable for individual patient tracking.

Limitations

  • The original study did not adjust for multiple comparisons in the segmental analysis.
  • The original study did not use a mixed-effects model to account for within-patient clustering of myocardial segments.

Cite This Study

Malik et al. (2026) conducted a letter in Chronic ischemic heart disease with reduced ejection fraction (n=55). Feature-tracking cardiac magnetic resonance (FT-CMR) vs. 2D speckle-tracking echocardiography (2D-STE) was evaluated on Global longitudinal strain (GLS) correlation (r = 0.793, p=<0.001). Feature-tracking cardiac magnetic resonance and 2D speckle-tracking echocardiography showed a strong global longitudinal strain correlation (r = 0.793), but limits of agreement spanned 8.3 percentage points, sufficient to misclassify individual patients.

synapsesocial.com/papers/6a2bd11d6550ea4541ffe87bhttps://doi.org/10.1186/s44348-026-00076-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A multicenter study on the comparability of myocardial strain values acquired with different CMR scanners and analyzed with different post-processing software: insights into the “Traveling Volunteers” study2025 · 4 citations
  2. 2Reliability of left ventricular global longitudinal strain across Acquisition and Analysis techniques: A Prospective Comparative Study2025 · 5 citations
  3. 3Measuring left ventricular global longitudinal strain in different contrast-enhanced echocardiography modes: a feasibility study2026
  4. 4Global Longitudinal Strain in Stress Echocardiography: A Review of Its Diagnostic and Prognostic Role in Noninvasive Cardiac Assessment2025
  5. 5Three-Dimensional Strain Parameters for Quantifying Replacement Fibrosis in Hypertrophic Cardiomyopathy2026