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June 6, 2026Frontiers in ImmunologyOpen Access

The relationship between gut microbiota and cancer immune response and immunotherapy

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Authors

YJYue JiaYLYuechuan LiuJLJ Q Liu

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Overview

Randomized trial investigates gut microbiota impact on immune response in cancer patients, suggesting it could enhance therapy effectiveness.

Key Points

  • This research aims to explore how gut microbiota influences cancer immunity and the effectiveness of immunotherapy.
  • Reviewed clinical studies linking gut microbiota compositions with responses to immune checkpoint inhibitors.
  • Investigated various therapeutic strategies, including fecal microbiota transplantation and dietary interventions.
  • Identified challenges related to engraftment and formulation consistency.
  • Specific microbial compositions are linked to improved responses to immune checkpoint inhibitors.
  • Gut microbiota can enhance therapeutic efficacy and reduce immune-related adverse events.
  • Need for well-designed large-scale studies to establish microbiota as a reliable prognostic biomarker.

Cite This Study

Jia et al. (2026) studied this question.

synapsesocial.com/papers/6a23b89f71a5da9775e74ca7https://doi.org/10.3389/fimmu.2026.1833138
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The gut microbiota in cancer immunity and immunotherapy2025 · 1 citations
  2. 2Gut microbiota shapes cancer immunotherapy responses2025
  3. 3The mechanisms and therapeutic potential of the microbiome-immune interface in cancer2025
  4. 4Role of gut microbiota in cancer modulation: molecular mechanisms and emerging therapeutic strategies2026
  5. 5Microbiome modulation of tumorigenesis and immune responses2026