Review highlights the role of gut microbiota in cancer immunity and therapeutic outcomes, revealing potential strategies for enhancing immunotherapy.
Key Points
An altered gut microbiota can promote immune evasion and enhance tumor survival, indicating its crucial role in cancer.
Beneficial commensal bacteria are emerging as probiotics for cancer therapy, supporting antitumor immunity by enhancing immune cell functions.
Mechanisms by which the gut microbiota affects immunotherapy include modulation of innate immune cells and CD8 + T cells, potentially improving treatment efficacy.
Approaches to target the gut microbiota, including probiotics and dietary modifications, may enhance immunotherapy outcomes while reducing adverse events.