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June 6, 2026Frontiers in ImmunologyOpen Access

The cGAS–STING pathway in cancer immunotherapy: prognostic value and therapeutic potential

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Authors

FAFaizah AlabiSISikiru O. ImodoyeKAKamoru A. Adedokun

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Overview

Review integrates mechanistic and clinical evidence on cGAS–STING for cancer therapy, highlighting its prognostic value and therapeutic potential.

Key Points

  • This review aims to evaluate the role of the cGAS–STING pathway in cancer immunotherapy as both a biomarker and therapeutic target.
  • Integration of mechanistic studies, preclinical evidence, and clinical outcomes across various tumor types.
  • Examination of cGAS–STING pathway activity in relation to immune responses and therapeutic efficacy.
  • Discussion of combination strategies and delivery platforms for STING activation.
  • Heightened cGAS–STING activity correlates with improved survival and response to immune checkpoint blockade in select tumors.
  • Pharmacologic activation of the cGAS–STING pathway suppresses tumor growth and increases immune cell presence.
  • Chronic STING activation may lead to immune exhaustion and adverse effects, impacting treatment efficacy.

Cite This Study

Alabi et al. (2026) studied this question.

synapsesocial.com/papers/6a23b80771a5da9775e74648https://doi.org/10.3389/fimmu.2026.1760947
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Also Consider

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  1. 1The cGAS‒STING pathway in colorectal cancer: bridging innate immunity and therapeutic strategies2025
  2. 2Advances in STING Pathway Modulation for Cancer and Immunotherapy: A Comprehensive Review of Preclinical and Clinical Studies (2020-2024).2025 · 3 citations
  3. 3Emerging cGAS‐STING Agonist‐Based Nanotherapeutics: Mechanistic Insights and Applications in Cancer Combination Therapy2025
  4. 4cGAS-STING signaling in the tumor microenvironment induces myeloid cell activation and favors T cell-mediated antitumor immunity2025 · 4 citations
  5. 5Nanocarrier-enabled STING agonist delivery for enhanced cancer immunotherapy2025