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May 30, 2026Journal of Clinical Oncology

Age-adjusted mortality rates for co-listed breast cancer and CLRD among US postmenopausal women declined from 1999 to 2017 (APC -0.80; P<0.001) but rose sharply from 2017 to 2020 (APC 4.41; P<0.001).

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Population

51,726 postmenopausal women in the United States with breast cancer and chronic lower respiratory diseases…

Design

Cohort

Follow-up

1999-2020

Key result

Age-adjusted mortality rates for co-listed breast cancer and CLRD among US postmenopausal women declined from 1999 to 2017 (APC -0.80; P<0.001) but rose sharply from 2017 to 2020 (APC 4.41; P<0.001).

Authors

MQMaria QadriAMAdnan MemonAHA Hidayat

Discussion

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Overview

Mortality rates for co-occurring breast cancer and CLRD in postmenopausal women declined until 2017 but have since risen sharply, with persistent disparities among Non-Hispanic Black women and rural populations.

Key Points

  • This analysis examines mortality trends involving breast cancer and chronic lower respiratory diseases among postmenopausal women in the U.S. from 1999 to 2020.
  • Analyzed CDC WONDER data from 1999 to 2020 for postmenopausal women (≥55 years) with breast cancer and CLRD as causes of death.
  • Calculated age-adjusted mortality rates (AAMRs) and assessed trends using Joinpoint regression to estimate annual percent change (APC).
  • A total of 51,726 deaths involved breast cancer and CLRD from 1999 to 2020.
  • Overall mortality rates declined from 1999 to 2017 (APC: -0.80; p < 0.001) but sharply increased from 2017 to 2020 (APC: 4.41; p < 0.001).
  • Significant disparities were noted, with Non-Hispanic Black women experiencing sustained increases in mortality (APC: 1.40; p = 0.0004).

Study Design

Type

Observational (n=51,726)

Multicenter

Yes

Structured PICO

P
Population
51,726 postmenopausal women (≥55 years) in the United States with breast cancer and chronic lower respiratory diseases (CLRD) listed as multiple causes of death.
O
Outcome
Age-adjusted mortality rates (AAMRs) per 100,000 population and annual percent change (APC)hard clinical

Main Result

Effect estimate: APC -0.80 (95% CI -1.02 to -0.58)

p-value: p=<0.001

Mortality rates for co-occurring breast cancer and CLRD in postmenopausal women declined until 2017 but have since risen sharply, with persistent disparities among Non-Hispanic Black women and rural populations.

Cite This Study

Qadri et al. (2026) conducted an observational in Breast cancer and chronic lower respiratory diseases (n=51,726). Age-adjusted mortality rates for co-listed breast cancer and CLRD among US postmenopausal women declined from 1999 to 2017 (APC -0.80; P<0.001) but rose sharply from 2017 to 2020 (APC 4.41; P<0.001).

synapsesocial.com/papers/6a1a82640307b7850943409ahttps://doi.org/10.1200/jco.2026.44.16_suppl.e13785
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Also Consider

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  5. 5Abstract C002: Racial and regional disparities in female genital cancer mortality in the United States, 1999–2020: A CDC WONDER and joinpoint regression analysis2025