PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
May 21, 2026Open Access

Practical Recommendations for Anticoagulation in Patients With Atrial Fibrillation.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does oral anticoagulation reduce stroke and mortality in patients with atrial fibrillation?

Population

Patients with atrial fibrillation

Comparison

Oral anticoagulation, including direct oral… vs No anticoagulation, or DOACs compared to VKAs

Design

Review

Authors

NJNicolas JohnerBGBaris Gencer

Discussion

Loading...

Member takes

Overview

Supports OAC initiation above 1-2% stroke risk in AF; reinforces RCT-derived net-benefit thresholds for practice.

Structured PICO

Does oral anticoagulation reduce stroke and mortality in patients with atrial fibrillation?

P
Population
Patients with atrial fibrillation
I
Intervention
Oral anticoagulation (OAC), including direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs)
C
Comparator
No anticoagulation, or DOACs compared to VKAs
O
Outcome
Stroke and systemic embolismhard clinical

This narrative review reinforces that oral anticoagulation is the cornerstone of thromboembolism prevention in atrial fibrillation, highlighting the preference for DOACs over VKAs in most patients.

Cite This Study

Johner et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea127be05d6e3efb5f89ehttps://doi.org/10.48620/97813
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Discontinuation of Oral Anticoagulation After Successful Catheter Ablation for Atrial Fibrillation: Meta-analysis of Randomized Clinical Trials2026
  2. 2Antithrombotic Management After Successful Catheter Ablation for Atrial Fibrillation: Meta-Analysis of the ALONE-AF and OCEAN Trials2026
  3. 3Real-World outcomes of oral anticoagulation in patients with atrial fibrillation at high risk of both bleeding anand Asia-Pacificd stroke: observational evidence from three international registries from middle East, Europe2025 · 4 citations
  4. 4Oral Anticoagulant Therapy in Patients with Atrial Fibrillation After Intracranial Hemorrhage: A Meta-Analysis of Randomized Controlled Trials2025
  5. 5Discontinuation of Oral Anticoagulants After Successful Atrial Fibrillation Ablation: A Systematic Review and Meta-Analysis2026