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This research aims to explore the association between uric acid to HDL cholesterol ratio and hepatic steatosis diagnosed via liver ultrasound.

Association Between Uric‐Acid‐to‐HDL Ratio and Hepatic Steatosis Diagnosed by Liver Ultrasound Transient Elastography

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This research aims to explore the association between uric acid to HDL cholesterol ratio and hepatic steatosis diagnosed via liver ultrasound.
Analyzed 3783 adults aged ≥ 18 years from the 2017-2018 NHANES cycle.
Used FibroScan to define hepatic steatosis as controlled attenuation parameter > 285 dB/m.
Applied complex-survey logistic regression and Cox models for statistical analysis.
Hepatic steatosis prevalence increased from 17.6% to 60.4% across UHR quartiles (P < 0.001).
Each 1-unit increase in UHR increased hepatic steatosis odds by 2.06 (95% CI 1.79–2.36).
Increasing UHR levels were associated with a 22% rise in all-cause mortality (HR 1.22, 95% CI 1.03–1.44).

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Randomized trial demonstrates a strong link between uric acid-HDL ratio and hepatic steatosis in adults, suggesting a potential screening tool.

Chu et al. (2026) studied this question.

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Randomized trial demonstrates a strong link between uric acid-HDL ratio and hepatic steatosis in adults, suggesting a potential screening tool.