August 20, 2025Frontiers in NeurologyOpen Access

Serum uric acid to high-density lipoprotein cholesterol ratio is associated with stroke in the elderly: a population-based study

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Higher serum uric acid to high-density lipoprotein cholesterol ratio is significantly associated with increased stroke risk in older adults.
In the highest quartile of uric acid to HDL cholesterol ratio, the odds ratio for stroke elevated to 1.48 after confounder adjustments.
A cross-sectional approach analyzed data from 16,562 participants aged 60 and older using logistic regression and ROC curves.
Results indicate that higher UHR levels correlate with a greater likelihood of stroke, particularly in non-diabetic populations.

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Cross-sectional study shows higher serum uric acid to HDL cholesterol ratios increase stroke risk in older adults, suggesting metabolic implications.

Jiang et al. (2025) studied this question.

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Cross-sectional study shows higher serum uric acid to HDL cholesterol ratios increase stroke risk in older adults, suggesting metabolic implications.