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April 13, 2026Vascular and Endovascular Surgery

Patients with CKD had comparable in-hospital mortality (aOR = 0.883, 95% CI = 0.671-1.163, P = .38) but higher risks of MACE (aOR = 1.519, 95% CI = 1.115-2.069, P = .01) and AKI (aOR = 1.933, 95% CI = 1.596-2.343, P < .01).

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Why the study?

Does chronic kidney disease increase the risk of in-hospital complications in patients undergoing type A aortic dissection repair?

Population

4,282 patients who underwent type A aortic dissection repair from the National Inpatient Sample.

Comparison

Presence of chronic kidney disease (CKD) vs Absence of chronic kidney disease (non-CKD)

Design

Cohort

Follow-up

in-hospital

Authors

RLRenxi LiDPDeyanira J. PrasteinSHStephen J. Huddleston

Discussion

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Overview

Chronic kidney disease is a significant risk factor for postoperative complications, particularly cardiac and renal events, following type A aortic dissection repair, although it does not significantly impact in-hospital mortality.

Key Points

  • This study aimed to evaluate the relationship between chronic kidney disease and outcomes following type A aortic dissection repair.
  • Analyzed a population-based sample from the National Inpatient Sample (2015-2020).
  • Compared in-hospital outcomes between CKD and non-CKD patients using multivariable logistic regressions.
  • Conducted subgroup analyses on mild, moderate, and severe CKD patients.
  • CKD patients showed a higher risk of major cardiovascular events, myocardial infarction, and acute kidney injury.
  • CKD patients had similar in-hospital mortality rates compared to non-CKD patients.
  • Mild-CKD patients had comparable outcomes to non-CKD, while moderate and severe-CKD patients faced increased complications.

Structured PICO

Does chronic kidney disease increase the risk of in-hospital complications in patients undergoing type A aortic dissection repair?

P
Population
4,282 patients who underwent type A aortic dissection (TAAD) repair from the National Inpatient Sample (2015-2020).
I
Intervention
Presence of chronic kidney disease (CKD)
C
Comparator
Absence of chronic kidney disease (non-CKD)
O
Outcome
In-hospital outcomes including mortality, major adverse cardiovascular events (MACE), myocardial infarction (MI), cardiogenic shock, mechanical ventilation, acute kidney injury (AKI), and pacemaker implantationhard clinical

Chronic kidney disease is a significant risk factor for postoperative complications, particularly cardiac and renal events, following type A aortic dissection repair, although it does not significantly impact in-hospital mortality.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69dc89183afacbeac03eacd7https://doi.org/10.1177/15385744261441979
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Incidence and risk factors of acute kidney injury after aortic dissection surgery].2025
  2. 2Trends and In‐Hospital Outcomes of Patients With Chronic Kidney Disease Hospitalised for Acute Myocardial Infarction With Chronic Total Occlusion: A Nationwide Analysis2025
  3. 3The Role of Other Major Postoperative Complications in Determining Outcomes of Acute Kidney Injury After Coronary Artery Bypass Surgery2025 · 4 citations
  4. 4The Impact of Dialysis on Postoperative Outcomes in Patients With Chronic Kidney Disease Undergoing Thoracolumbar Trauma Repair2025
  5. 5Transcatheter Aortic Valve Implantation in Patients with Chronic Kidney Disease: A Comprehensive Systematic Review and Qualitative Evidence Synthesis2025