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January 9, 2026The Heart Surgery ForumOpen Access

Development and Validation of a Prognostic Nomogram Integrating CMR and Clinical Data for Predicting 1- to 3-Year Major Adverse Cardiovascular Events in New-Onset STEMI Patients Post-PCI

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Key result

The validated prognostic nomogram effectively discriminates high- and low-risk new-onset STEMI patients for MACE at 1-, 2-, and 3-years post-PCI.

Authors

SWShancheng null WangLYLei null YangYZYu null Zhang

Discussion

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Overview

Retrospective study develops a prognostic tool predicting MACE in STEMI patients post-PCI, suggesting improved risk assessment.

Key Points

  • This study aims to develop and validate a nomogram that combines CMR and clinical data to predict MACE in new-onset STEMI patients post-PCI.
  • Retrospective study including STEMI patients who underwent PCI from January 2020 to June 2022.
  • Cohorts were divided into a derivation group for model development and a validation group.
  • Cox proportional hazards regression analyses identified independent risk factors.
  • Predictive performance assessed using C-indexes and ROC curves.
  • Cumulative MACE rates at 1, 2, and 3 years were 20.6%, 34.6%, and 44.9% in the derivation cohort, and 21.7%, 34.8%, and 50.0% in the validation cohort.
  • The final nomogram included six important predictors from clinical and CMR data.
  • The nomogram showed good discrimination (C-index: 0.803) in the derivation cohort and moderate in the validation cohort (C-index: 0.693).
  • Calibration plots indicated good agreement between predicted and observed MACE probabilities.

Study Design

Type

Cohort (n=153)

Blinding

null

Randomization

null

Multicenter

Yes

PICO

P
Population
ST-segment elevation myocardial infarction (STEMI) (n=153)
I
Intervention / Comparator
CMR integrated nomogram vs null (null)
O
Primary Outcome
Major adverse cardiovascular events (MACE) — null (null), p=null

Main Result

Effect estimate: null (95% CI null)

p-value: p=null

Limitations

  • Retrospective study design
  • Single-center and multi-center data may limit generalizability
  • Potential selection and survival bias in cohort study design

Cite This Study

Wang et al. (2025) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=153). CMR integrated nomogram vs. null was evaluated on Major adverse cardiovascular events (MACE) (null, 95% CI null, p=null). The validated prognostic nomogram effectively discriminates high- and low-risk new-onset STEMI patients for MACE at 1-, 2-, and 3-years post-PCI.

synapsesocial.com/papers/69612feb30ef6c21f6854026https://doi.org/10.31083/hsf49261
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A predictive nomogram for intramyocardial hemorrhage in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention based on coronary angiography-derived index of microcirculatory resistance2025 · 2 citations
  2. 2A nomogram model based on HALP score and sST2 for predicting 1-year MACE risk after PCI in acute myocardial infarction patients2025 · 1 citations
  3. 3Nomogram model for predicting multivessel disease in coronary artery disease using cardiac function parameters and clinical features2026
  4. 4Development of a Risk Prediction Model for Major Adverse Cardiovascular Events After PCI in Patients with Coronary Heart Disease2025
  5. 5Development and validation of a triglyceride-glucose index-based nomogram for predicting risk in STEMI patients undergoing primary PCI2026