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January 9, 2026Journal of General and Family MedicineOpen Access

Depression is strongly associated with polypharmacy in older adults, with an odds ratio of 2.49, indicating a significant increase in risk.

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Key result

Depression is strongly associated with polypharmacy in older adults, with an odds ratio of 2.49, indicating a significant increase in risk.

Authors

YWYi‐Hsin WangTTTsung‐Yu TsaiHCHung‐Chang Chou

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Overview

Systematic review finds a strong link between depression and polypharmacy in older adults, suggesting integration of mental health in medication management.

Key Points

  • This research aims to evaluate the relationship between depression and polypharmacy in older adults.
  • Conducted a systematic review and meta-analysis of existing studies.
  • Searched databases including EMBASE, PubMed, Web of Science, and PsycINFO.
  • Registered the review in PROSPERO.
  • Included studies based on specific criteria, resulting in eight studies analyzed.
  • Pooled analysis showed a strong association between depression and polypharmacy (OR = 2.49).
  • The confidence interval was 95% (1.88–3.29), indicating a significant relationship.
  • I² value of 83% suggests high variability among studies.
  • Consistent elevated associations found in both community-based and institutional populations.

Cite This Study

Wang et al. (2026) studied this question. Depression is strongly associated with polypharmacy in older adults, with an odds ratio of 2.49, indicating a significant increase in risk.

synapsesocial.com/papers/69612fd930ef6c21f6853d8fhttps://doi.org/10.1002/jgf2.70094
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Global prevalence, trends, and dose-response associations of polypharmacy in older adults2026 · 3 citations
  2. 2Navigating Polypharmacy in Elderly Psychiatric Patients: A Review of the Literature2025
  3. 3Association between Anxiety and Depression with Sleep Quality among Iraqi Polypharmacy Older Adults: A Cross-Sectional Study2025
  4. 4A Systematic Review and Meta-analysis of the Global Prevalence of Depression in Older Adults with Multi-morbidity2025 · 3 citations
  5. 5Polypharmacy in the older patient2025