PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
January 9, 2026Annals of Pharmacotherapy

Evaluation of the Use of Primary Prevention Aspirin in Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant for Stroke Prevention

View Full Paper
Ask AI
Bookmark
Share

Key result

Adding low-dose aspirin to DOAC therapy in patients with AF significantly increased major bleeding risk (5.74 vs 1.37 per 100 patient-years) without reducing ischemic events.

Authors

SYStoree YzaguirreMRMatthew RockholdTSThomas W. Szymanski

Discussion

Loading...

Member takes

Overview

Multicenter cohort study evaluates bleeding risk in atrial fibrillation patients taking aspirin and anticoagulants, suggesting safety concerns.

Key Points

  • This study aimed to evaluate the safety and efficacy of low-dose aspirin for primary ASCVD prevention in patients with atrial fibrillation receiving DOAC therapy.
  • Conducted as a multicenter, retrospective cohort study.
  • Compared patients using apixaban or rivaroxaban plus low-dose aspirin (combination therapy) with those on DOAC monotherapy.
  • Included patients aged 18 to 79 with atrial fibrillation and no history of atherosclerotic cardiovascular disease.
  • Measured incidence of major bleeding and clinically relevant non-major bleeding as safety endpoints.
  • 611 patients were included, with major bleeding incidence significantly lower in the DOAC monotherapy group (1.37 vs 5.74 per 100 patient-years).
  • Combination therapy was associated with a higher risk of major bleeding (odds ratio = 3.15).
  • No significant difference in ischemic events between groups.

Cite This Study

Yzaguirre et al. (2025) studied this question. Adding low-dose aspirin to DOAC therapy in patients with AF significantly increased major bleeding risk (5.74 vs 1.37 per 100 patient-years) without reducing ischemic events.

synapsesocial.com/papers/69609561f6dae357db7c13fehttps://doi.org/10.1177/10600280251401892
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk2026
  2. 22188-P: Clinical Benefits and Risks of Reduced-Dose vs. Standard-Dose Direct Oral Anticoagulants in Patients with Atrial Fibrillation: An Observational Analysis of Veterans Affairs Data2026
  3. 3Dual Antithrombotic Therapy Versus Anticoagulation Alone After Ischemic Stroke in Patients With Atrial Fibrillation and Atherosclerotic Disease: A Meta-Analysis of Efficacy and Safety Outcomes2026
  4. 4Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation2025 · 66 citations
  5. 5Impact of aspirin use on clinical outcomes in antiphospholipid syndrome patients with arterial thrombosis: A real-world cohort study2025