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December 23, 2025JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIAOpen Access

Hypoxia-inducible Factor-2α Probably Mediated the Toxicities of Intravenous Beta-Cyclodextrin in Normal and Diabetic Rats’ Kidneys

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Authors

APAnita PurnamayantiSSSuharjono SuharjonoMRMahardian Rahmadi

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Overview

This study investigates nephrotoxicity induced by beta-cyclodextrin in rats, highlighting renal function decline and involvement of hypoxia-inducible factors.

Key Points

  • The study examines the nephrotoxic effects of intravenous beta-cyclodextrin and its molecular mechanisms.
  • Sixteen Wistar rats were used, divided into healthy and diabetic groups.
  • Both groups received daily intravenous injections of either water or a 6% beta-cyclodextrin solution for 28 days.
  • Histopathology was analyzed semi-quantitatively on a 0-5 score basis.
  • RT-PCR quantified the mRNA expression of relevant markers, including HIF-1, HIF-2 and IL-6.
  • No deaths occurred in any group, but renal function declined in test groups.
  • Histopathological analysis revealed vascular integrity issues, cellular infiltration, and necrosis.
  • mRNA expressions of hypoxia-inducible factors were upregulated, indicating regional renal hypoxia.

Cite This Study

Purnamayanti et al. (2025) studied this question.

synapsesocial.com/papers/6949ddb572f746a93d788f71https://doi.org/10.20473/jfiki.v12i32025.372-381
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