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December 8, 2025Blood

Quantitative profiling and clinical correlative analysis of fibrocytes and mesenchymal stromal cells in myelofibrosis spleen

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Authors

TMTaghi ManshouriCLChristopher LyADAndrew Dunbar

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Overview

Multiplex imaging reveals fibrocyte reduction in myelofibrosis spleens, suggesting altered splenic remodeling.

Key Points

  • Reduced fibrocyte numbers in myelofibrosis spleens indicate altered cellular dynamics.
  • Histologically confirmed pathology includes splenomegaly and distinct megakaryocyte clusters in spleens.
  • Targeted mutational profiling assessed key genes like JAK2V617F, CALR, and MPL in bone marrow and spleen samples.
  • Correlation between fibrocytes and advanced disease in myelofibrosis highlights the role of these cells in spleen pathology.

Cite This Study

Manshouri et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e59dhttps://doi.org/10.1182/blood-2025-5542
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcriptomic analysis of CD34⁺ cells in myelofibrosis highlights their role in extracellular matrix dysregulation and marrow fibrosis2025 · 1 citations
  2. 2Advanced myelofibrosis is marked by loss of NKG2D and DNAM-1 NK activating signaling and increased TIM-3 T CD8 exhaustion2025
  3. 3Clonal architecture inferred from routine NGS data predicts outcome and response to JAK-inhibitors in myelofibrosis2025
  4. 4Magnetic resonance imaging maps spatiotemporal changes in bone marrow composition of murine JAKV617F models of myelofibrosis during progression and therapy2025
  5. 5Long-term outcome and risk factors for relapse after allogeneic hematopoietic stem cell transplantation in myelofibrosis: Results from a large multicenter cohort2025