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December 8, 2025BloodOpen Access

Magnetic resonance imaging maps spatiotemporal changes in bone marrow composition of murine JAKV617F models of myelofibrosis during progression and therapy

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Authors

YJYoungsoon JangDMDariya Malyarenko

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Overview

Analysis reveals treatment response and fibrosis alterations in myelofibrosis with imaging methods, suggesting new therapeutic insights.

Key Points

  • Non-invasive MRI detects bone marrow composition changes in myelofibrosis, highlighting treatment responses.
  • Approximately 35% reduction in spleen volume was observed in treated murine models compared to vehicle.
  • Diffusion-weighted MRI correlated with bone marrow and Ruxolitinib treatment efficacy in Jak2+/V617F mice.
  • Findings suggest potential for MRI in monitoring hematologic cancers alongside myelofibrosis.

Cite This Study

Jang et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d985https://doi.org/10.1182/blood-2025-2560
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Momelotinib inhibition of JAK/STAT in a mouse JAKV617F myelofibrosis model showed concurrent activation of p-ERK and p-AKT which was reversed by combination therapy using LP-182, a novel MEK/PI3K/mTOR inhibitor2025
  2. 2EP31670, a dual-BET + p300 inhibitor, demonstrates pre-clinical efficacy, including in combination with JAK inhibition, in the hMPLW515L adoptive transfer model of myelofibrosis (MF)2025 · 2 citations
  3. 3Transcriptomic analysis of CD34⁺ cells in myelofibrosis highlights their role in extracellular matrix dysregulation and marrow fibrosis2025 · 1 citations
  4. 4Clonal architecture inferred from routine NGS data predicts outcome and response to JAK-inhibitors in myelofibrosis2025
  5. 5Quantitative profiling and clinical correlative analysis of fibrocytes and mesenchymal stromal cells in myelofibrosis spleen2025