Monitoring of measurable residual disease by next‐generation sequencing in patients with acute myeloid leukaemia

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Observational analysis evaluated overall survival and relapse-free survival in AML patients, indicating NGS-MRD's prognostic role.

NGS-MRD positivity >0.1% showed a significant association with worse outcomes after two chemotherapy courses.
Combining NGS-MRD with MFC-MRD highlighted a subgroup with extremely poor overall survival rates of HR = 7.98.
The duplex UMI-based NGS method demonstrated a 20-fold reduction in false positives compared to conventional sequencing.
Accurate quantification was confirmed down to 0.01% variant allele frequency with serial dilution analyses.

Boudry et al. (2025) studied this question.

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View Full Paper

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Authors

Observational analysis evaluated overall survival and relapse-free survival in AML patients, indicating NGS-MRD's prognostic role.

NGS-MRD positivity >0.1% showed a significant association with worse outcomes after two chemotherapy courses.
Combining NGS-MRD with MFC-MRD highlighted a subgroup with extremely poor overall survival rates of HR = 7.98.
The duplex UMI-based NGS method demonstrated a 20-fold reduction in false positives compared to conventional sequencing.
Accurate quantification was confirmed down to 0.01% variant allele frequency with serial dilution analyses.

Boudry et al. (2025) studied this question.

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