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December 8, 2025BloodOpen Access

Impact of angiotensin-converting enzyme inhibitors (ACEis) or angiotensin II receptor blockers (ARBs) on kidney functions in allogeneic stem cell transplant patients receiving tacrolimus

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Authors

SJSaad Javaid

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Overview

Retrospective analysis reports increased acute kidney injury and proteinuria in patients on tacrolimus and angiotensin II receptor blockers following hematopoietic stem cell transplantation.

Key Points

  • AKI incidence was higher in patients receiving angiotensin II receptor blockers with tacrolimus, representing 35% vs 31%.
  • Retrospective analysis using propensity score matching compared two groups across demographic and clinical variables.
  • The proportion of patients experiencing proteinuria was significantly greater in the ACEi/ARB cohort, at 25% compared to 17%.
  • Limitations include potential residual confounding despite propensity score matching and variability in follow-up data.

Cite This Study

Saad Javaid (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e516https://doi.org/10.1182/blood-2025-2503
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of angiotensin converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARB) on tumor lysis syndrome, acute kidney injury, and rasburicase use in patients undergoing chemotherapy for hematologic malignancies2025
  2. 2Preliminary Evaluation of Tacrolimus Impact on Glycemic Control, Renal Function, and Hematological Inflammatory Markers in Kidney Transplant Recipients2025 · 1 citations
  3. 3Impact of early tacrolimus levels on survival outcomes following allogeneic hematopoietic stem cell transplantation.2026
  4. 4Effect of GVHD prophylaxis on renal function and survival outcomes in allogeneic hematopoietic cell transplant patients with pre-existing renal impairment2025
  5. 5Risk of malignant neoplasms of tacrolimus in kidney transplant patients: a retrospective cohort study conducted using the Japanese National Database of Health Insurance Claims2025 · 1 citations