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December 8, 2025Blood

Effect of GVHD prophylaxis on renal function and survival outcomes in allogeneic hematopoietic cell transplant patients with pre-existing renal impairment

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Authors

MVMariola Vazquez‐MartinezTCTeresa CapriceJKJongphil Kim

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Overview

Retrospective analysis shows GVHD prophylaxis type affects acute kidney injury and renal outcomes in patients with pre-existing renal impairment.

Key Points

  • Acute kidney injury incidence was 47% overall, with variations in regimens like 33% for PTCy/SIR.
  • Multivariate analysis indicated PTCy/SIR mitigates renal toxicity risk compared to other regimens.
  • Renal function outcomes were significantly influenced by pre-HCT renal impairment and HCT-CI scores.
  • Established predictive factors for non-relapse mortality include age over 60 and high HCT-CI scores.

Cite This Study

Vazquez‐Martinez et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d415https://doi.org/10.1182/blood-2025-7764
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Post-transplant cyclophosphamide-based graft-verses-host disease (GVHD) prophylaxis is associated with a low incidence of fibrotic chronic GVHD after allogeneic hematopoietic cell transplantation across diverse donor types2025
  2. 2Phase II Study of post transplant cyclophosphamide-based graft versus host disease prophylaxis after HLA-mismatched unrelated donor transplantation and reduced intensity conditioning: Results from the NMDP-sponsored access expansion Study2025
  3. 3Impact of conditioning intensity on outcomes after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis2025
  4. 4Impact of graft versus host disease prophylaxis with post transplant cyclophosphamide on the prognostic value of HCT-CI2025
  5. 5Comorbid but transplantable: Favorable outcomes with RIC and ptcy in patients with an HCT-CI score of 3 or higher in the modern era2025