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December 8, 2025BloodOpen Access

Trends in transplantation for patients with myelodysplastic syndrome across recent decades: A registry-based study on behalf of the chronic malignancies working of the EBMT

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Authors

VPVictoria PotterHSHenrik SengeloevRLRégis Peffault de Latour

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Overview

Registry-based analysis reveals improved overall and relapse-free survival rates in myelodysplastic syndrome patients undergoing HSCT with cord blood.

Key Points

  • Overall survival and relapse-free survival improved over time, with 4-year survival rates reaching 53% in recent years.
  • Cox proportional hazards models identified older age and donor type as significant risk factors impacting outcomes.
  • Analysis included 18,710 patients receiving HSCT from 2000-2022, with non-relapse mortality also decreasing significantly.
  • Findings may suggest evolving transplant strategies and improved management of complications in HSCT.

Cite This Study

Potter et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4fahttps://doi.org/10.1182/blood-2025-375
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential trends in survival after allogeneic transplantation for MDS and MDS/MPN in a real-world experience2025
  2. 2National Trends and In-Hospital Outcomes of Hematopoietic Stem Cell Transplant in Myelodysplastic Syndromes, 2016–20202025
  3. 3In-hospital mortality and complications are increased in hematopoietic stem cell transplant recipients with myelodysplastic syndromes2026
  4. 4Temporal trends in overall survival among patients with high-risk MDS: Insights from the spanish MDS registry (RESMD)2025
  5. 5Impact of allogeneic transplant vs hypomethylating agents in high-risk myelodysplastic syndromes: A prisma-guided systematic review2025