Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Granulocyte maturation and splicing defects in DDX41-mutated leukemia

View Full Paper
Ask AI
Bookmark
Share

Authors

ARAyush T. RamanCSCaner SayginLXLiqiang Xi

Discussion

Loading...

Member takes

Overview

Analysis reveals granulocyte maturation defects and splicing anomalies in DDX41-related leukemia, suggesting intrinsic RNA processing roles.

Key Points

  • Granulocyte maturation defects result from DDX41 mutations, impacting AML progression and survival.
  • RNA-seq identified 24,336 genes and TMT-MS revealed 4,787 proteins related to DDX41 mutations.
  • Observational analysis focused on gene expression differences with PCR and CRISPR/Cas9 targeting intrinsic splicing mechanisms.
  • Outcomes indicate compromised innate immunity and abnormal cellular differentiation in DDX41-mutated leukemia cases.

Cite This Study

Raman et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4b7https://doi.org/10.1182/blood-2025-1439
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DDX41-R525H mutation promotes dysplastic hematopoiesis via aberrant splicing of key regulators of HSC biology2025 · 1 citations
  2. 2The somatic DDX41 hot spot mutation (p.R525H) causes skewed differentiation into plasmacytoid dendritic cells in human iPSC and leukemia models2025
  3. 3Unsupervised clustering of DDX41 mutants informs on the somatic landscape of single germline hits2025
  4. 4Exploring the spectrum of non-malignant complications in germline DDX41-associated hematologic disorders2025
  5. 5Decoding DDX41: Clinical impact of germline and somatic mutations in 77 high-risk myeloid neoplasm patients2025 · 1 citations