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December 8, 2025BloodOpen Access

Decoding DDX41: Clinical impact of germline and somatic mutations in 77 high-risk myeloid neoplasm patients

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Authors

HMHemant S. MurthyAMAbhishek A. MangaonkarJJJennifer Jiang

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Overview

Retrospective study reports outcomes in patients with DDX41 mutations, indicating therapy response varies with clinical characteristics.

Key Points

  • Overall survival among patients with DDX41 mutations was 56.9 months, with a median follow-up of 34.7 months.
  • High-risk myeloid neoplasms were treated with venetoclax-based therapies or intensive chemotherapy, with no significant difference in outcomes.
  • Stem cell transplantation was performed in 40% of patients, highlighting potential treatment pathways for those with DDX41 mutations.
  • Multivariable analysis identified concurrent splicing factor mutations as a negative prognostic factor for overall survival.

Cite This Study

Murthy et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e449https://doi.org/10.1182/blood-2025-1442
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DDX41-related myeloid neoplasms: Insights and treatment landscape in 250 patients managed at a large tertiary centre2025
  2. 2Improved outcomes following allogeneic hematopoietic stem cell transplantation in patients with DDX41-mutated myeloid neoplasms: A prospective analysis of survival, GVHD, and transplant-related mortality2025
  3. 3Outcomes and characteristics of patients treated with frontline intensive chemotherapy versus hypomethylating agent/venetoclax-based therapy in DDX41-mutated Acute Myeloid Leukemia (AML)2025
  4. 4Allogeneic hematopoietic stem cell transplantation in patients with germ line DDX41 mutated myeloid malignancies2025 · 7 citations
  5. 5Unsupervised clustering of DDX41 mutants informs on the somatic landscape of single germline hits2025