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December 8, 2025Blood

Activation of endogenous retroviral elements drives inflammation and transformation in STAG2-mutant myeloid malignancies

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Authors

AWAmy WangGLG Raisz LawrenceKCKarl R. Clauser

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Overview

Observational analysis revealed double-stranded RNA drives inflammation in myeloid malignancies, suggesting implications for therapeutic strategies.

Key Points

  • Increased double-stranded RNA in STAG2-mutant hematopoietic stem cells leads to inflammatory responses in myeloid malignancies.
  • Patients with STAG2-mutant MDS showed higher Type 1 IFN signaling compared to wild-type counterparts.
  • Examination of isogenic cell lines provided insights into transposable element expression patterns in STAG2-mutant cells.
  • Findings may enable novel therapeutic approaches targeting ERV reactivation in MDS.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e377https://doi.org/10.1182/blood-2025-987
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1STAG2 mutation preserves a stem cell phenotype in FLT3-ITD-mediated MDS to leukemia transformation2025
  2. 2Enhanced FLI1 accessibility mediates STAG2-mutant leukemogenesis2025
  3. 3Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome2025
  4. 4ST2 promotes leukemia transformation by reshaping the immune landscape in Acute Myeloid Leukemia2025
  5. 5Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome2025