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December 8, 2025Blood

STAG2 mutation preserves a stem cell phenotype in FLT3-ITD-mediated MDS to leukemia transformation

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Authors

VSVarun SudunaguntaRBRobert L. Bowman

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Overview

Sequential mutagenesis reveals Stag2 mutation sustains hematopoietic stem cell presence in leukemia, indicating altered differentiation patterns.

Key Points

  • Hematopoietic stem cells are preserved in the Stag2 mutant model during leukemia transformation, unlike in FLT3-ITD.
  • Differentiation capacity is blocked in the presence of FLT3-ITD, yet activated in Stag2 mutant scenarios.
  • Analysis employed scRNAseq and bulk RNAseq to investigate transcription factors and cellular behaviors in AML models.
  • Findings suggest a potential pre-clinical testing platform for AML-MRC pathogenesis and therapies.

Cite This Study

Sudunagunta et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4b6https://doi.org/10.1182/blood-2025-3242
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