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December 8, 2025Blood

Mavs mediates inflammatory memory in hematopoietic stem cells and promotes ineffective hematopoiesis

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Authors

JXJuying XuMJMichael B. JordanMFMarie–Dominique Filippi

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Overview

Observational analysis demonstrated altered transcription and caspase-1 activity in hematopoietic stem cells, indicating MAVS may link inflammation to myelodysplastic syndromes.

Key Points

  • Hematopoietic stem cells showed altered transcription and epigenetic remodeling after inflammatory stress, with increased caspase-1 activity.
  • RNA-seq identified significant immune gene expression patterns in hematopoietic stem cells after polyIC treatments.
  • Analysis using polyinosinic-polycytidylic acid challenges showed sustained caspase-1 activation linked to the inflammasome in stem cells.
  • Inflammatory memory and metabolic dysregulation may indicate potential therapeutic targets for myelodysplastic syndromes.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e36bhttps://doi.org/10.1182/blood-2025-974
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  4. 4From mitochondria to heart: the role and challenges of mitochondrial antiviral signaling protein in cardiovascular disease2025
  5. 5Transcriptional and splicing dysregulation by U2AF1 mutations contribute to inflammatory and migratory alterations in MDS2025