December 8, 2025BloodOpen Access

Pattern of infections and impact on immunocompetence of next generation B-cell depleting immunotherapies in non-Hodgkin's lymphomas: Results from a multicentre retrospective real- life cohort.

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ACAlessia Castellino LNLuigi NigriItalian Society of Physiotherapy MBMatteo Bisio

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Implication

Observational analysis revealed a high incidence of bacterial and viral infections in NHL patients post-immunotherapy, suggesting careful monitoring is vital.

Key Points

Infections are common complications during novel immunotherapy treatments in non-Hodgkin's lymphomas.
Seventy-two total infective events were recorded, with 64% being bacterial infections.
Observational analysis across three Italian centers evaluated infection patterns in NHL patients treated with novel immunotherapies.
Significant mortality occurred from lymphoma progression, highlighting disease severity over treatment complications.

Cite This Study

Castellino et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e260 https://doi.org/10.1182/blood-2025-5499

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Implication

Observational analysis revealed a high incidence of bacterial and viral infections in NHL patients post-immunotherapy, suggesting careful monitoring is vital.

Pattern of infections and impact on immunocompetence of next generation B-cell depleting immunotherapies in non-Hodgkin's lymphomas: Results from a multicentre retrospective real- life cohort.

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Implication

Key Points

Cite This Study

Pattern of infections and impact on immunocompetence of next generation B-cell depleting immunotherapies in non-Hodgkin's lymphomas: Results from a multicentre retrospective real- life cohort.

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