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December 8, 2025BloodOpen Access

Impact of pomalidomide-containing induction chemotherapy on hematopoietic stem cell mobilization in multiple myeloma: A retrospective cohort study

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LKLifen Kuang

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Overview

Retrospective cohort study shows elevated incidence of poor mobilizers in multiple myeloma with pomalidomide, suggesting necessary adjustments in mobilization strategies.

Key Points

  • Increased incidence of poor mobilizer patients in those treated with pomalidomide, indicating a potential hurdle in treatment.
  • Retrospective cohort study revealed 27.3% poor mobilizer incidence in pomalidomide group vs 17.6% non-pomalidomide group.
  • Assessment of mobilization outcomes using G-CSF and plerixafor among stem cell transplant-eligible patients.
  • Implications highlight the necessity of tailored mobilization strategies for patients receiving pomalidomide.

Cite This Study

Lifen Kuang (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e250https://doi.org/10.1182/blood-2025-7545
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world stratified treatment strategies in transplant-eligible newly diagnosed multiple myeloma: A multicohort study2025
  2. 2Pomalidomide significantly enhances the antitumor immune efficacy of dendritic cell-derived exosomes from multiple myeloma patients2026
  3. 3Pomalidomide promotes activation induced cell death of pre-activated, memory BCMA CAR-T cells in a model of high, but not low, tumor burden multiple myeloma2025 · 1 citations
  4. 4Etoposide + cytarabine + pegfilgrastim vs cyclophosphamide + granulocyte colony-stimulating factor for stem-cell mobilization in patients with multiple myeloma: A phase III trial2025
  5. 5Motixafortide + G-CSF hematopoietic stem cell mobilization in patients with multiple myeloma following quadruplet induction therapy2025