Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Is dual targeting of FXII and Gas6 a good strategy to prevent thrombosis with no risks of bleeding?

View Full Paper
Ask AI
Bookmark
Share

Authors

ISIlaria De SimoneAAAnne Angelillo‐Scherrer

Discussion

Loading...

Member takes

Overview

Observational analysis found dual targeting of FXII and Gas6 reduces thrombosis in knockout mice, suggesting safer anticoagulant strategies may exist.

Key Points

  • Reduced thrombus formation observed in double knockout mice compared to wild-type mice, indicating significant changes in thrombosis dynamics.
  • Bleeding times in knockout mice were shorter than wild-type, demonstrating a potential for bleeding-free anticoagulation strategies.
  • Assessment using ultrahigh-frequency ultrasound showed less vena cava occlusion in knockout models after thromboembolism induction.
  • Inhibition of Gas6 may provide a more effective and safer approach for thrombosis prevention, highlighting the complexity of combining anticoagulation factors.

Cite This Study

Simone et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e18ehttps://doi.org/10.1182/blood-2025-14
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhancing hemostasis in glanzmann thrombasthenia via protein S inhibition2025
  2. 2Potent Inhibition of Arterial Thrombosis and Venous Thrombogenesis Subject to Adequate Hemostasis via Disrupting β3/Src Interaction in Platelets2025
  3. 3Phosphatidylserine-rich platelet blebs enhance hemostasis after mucous membrane injury but not after skin or vascular injury: Studies with ANO6-deficient mice2025
  4. 4Increased FXII activation in endovascular treated stroke patients on periprocedural antithrombotic treatment2025
  5. 5Impact of secondary FVIII prophylaxis on joint bleeding and arthropathy in a Hemophilia A mouse model lacking inhibitor response2025