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December 8, 2025Blood

Apheresis blood processing with heparin improves stem cell collection outcomes for sickle cell gene therapy

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Authors

CHCarly HowardASAimee SarnieSNSarah Nikiforow

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Overview

Observational analysis improved collection efficiency in sickle cell disease, highlighting the need for better gene therapy outcomes.

Key Points

  • Collection efficiency improved with heparin, resulting in a mean yield of 5.5 × 10⁶ CD34+ cells/kg compared to 3.4 × 10⁶ without.
  • In 91 procedures, access pressure alarms occurred in only 2% with heparin, versus 21% without, indicating fewer complications.
  • Assessment compared ACD-A and heparin in apheresis for hematopoietic progenitor cell collections from peripheral blood.
  • These findings support heparin's potential to optimize outcomes in gene therapy protocols for sickle cell disease.

Cite This Study

Howard et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e142https://doi.org/10.1182/blood-2025-6096
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Highly efficient collection and manufacture of autologous HSC gene therapy cell product for patients with sickle cell disease using a lentiviral vector containing a shmir targeting BCL11a2025 · 1 citations
  2. 2Effectiveness and challenges of apheresis of peripheral blood stem cells in children with malignant neoplasms: results of a single-center study2025
  3. 3Individualizing apheresis processing volumes using a predictive algorithm: Analysis of the CAR T-cell collection protocol utilized in ACIT001/EXC002, a phase lb/ll trial of decentralized production of CAR T-cells for treatment of relapsed/refractory aggressive NHL and ALL2025
  4. 4Impact of New Hematopoietic Progenitor Cell Collection Goals on Apheresis and Cell Therapy Laboratory Services2025
  5. 5Real-world experience with apheresis for gene therapy in transfusion-dependent β-thalassemia: The largest single-center report2025