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December 8, 2025BloodOpen Access

High protein expression of MDS1 and EVI1 complex locus (MECOM) is prognostically adverse and independent of chromosome 3 rearrangements in acute myelogenous leukemia

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Authors

SKSteven M. KornblauBBBrandon BrownYQYihua Qiu

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Overview

Analysis reveals high EVI1 expression in acute myelogenous leukemia predicts poor outcomes, indicating utility in proteomics for identifying at-risk patients.

Key Points

  • High EVI1 expression correlates with poor outcomes in acute myelogenous leukemia, emphasizing its prognostic value.
  • Patients categorized by EVI1 levels showed marked differences in overall survival, particularly between high and low groups.
  • Observational analysis of differential expression in 806 acute myelogenous leukemia patients, revealing significant findings across chromosome 3 alterations.
  • Findings suggest proteomics could identify patients with EVI1 elevation, broadening treatment options beyond traditional MECOM-R classifications.

Cite This Study

Kornblau et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236e04chttps://doi.org/10.1182/blood-2025-5258
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low levels of enhancer of zeste homolog 2 (EZH2) protein are prognostically adverse and independent of mutation status in acute myelogenous leukemia.2025
  2. 2Characteristics and clinical outcomes of patients (pts) with Acute Myeloid Leukemia (AML) with Mecom rearrangements: An analysis from the MARROW consortium2025
  3. 3MECOM fusion partner and bone marrow blast percentage influence outcomes of patients with MECOM rearranged acute myeloid leukaemia2025 · 4 citations
  4. 4Proteogenomic analysis of NPM1-mutated AML reveals clinical heterogeneity related to differentiation states and mitochondrial metabolism2025
  5. 5Changing dogma regarding mutation primacy in acute myelogenous leukemia : Protein expression supersedes mutation status2025