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December 8, 2025Blood

Changing dogma regarding mutation primacy in acute myelogenous leukemia : Protein expression supersedes mutation status

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Authors

EMEunice MagalhãesBBBrandon BrownSCSamanta Catueno

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Overview

Analysis reveals that mutation impact on prognosis in acute myelogenous leukemia is superseded by protein expression levels.

Key Points

  • Survival outcomes in acute myelogenous leukemia are significantly influenced by protein levels, not just mutations.
  • Fourteen out of seventeen evaluated proteins affected overall survival, emphasizing the role of protein expression in prognosis.
  • Analysis using reverse phase protein arrays assessed 438 proteins in 805 acute myelogenous leukemia cases for prognostic impact.
  • Findings suggest protein expression patterns can enhance therapy targeting and patient classification in acute myelogenous leukemia.

Cite This Study

Magalhães et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236d9fdhttps://doi.org/10.1182/blood-2025-3492
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