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December 8, 2025Blood

Real-world data on cardiovascular disease incidence in adults with acquired immune aplastic anemia.

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Authors

MOMayowa Oturoko

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Overview

Retrospective analysis reports cardiovascular disease incidence in 77 adults with acquired aplastic anemia, indicating high ischemic risk and contributions of treatment factors.

Key Points

  • Eighteen patients had pathogenic mutations detected via next-generation sequencing, indicating a role in cardiovascular disease outcomes.
  • Among 77 patients, 32% developed cardiovascular disease, most frequently myocardial infarctions and transient arrhythmias.
  • Anti-thymocyte globulin treatment exposure was associated with temporal linking to arrhythmias and new cardiovascular events.
  • Clonal hematopoiesis and treatment exposure necessitate further study in larger cohorts for clearer associations with ischemic risks.

Cite This Study

Mayowa Oturoko (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dff9https://doi.org/10.1182/blood-2025-4984
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Also Consider

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  1. 1Aplastic anemia in patients admitted to the hospital: Clinical characteristics, risk stratification, and outcomes from a large inpatient care database2025
  2. 2Clonal hematopoiesis may precede the diagnosis of aplastic anemia by several years2025
  3. 3Clonal architecture and dynamics of somatic evolution in aplastic anemia and paroxysmal nocturnal hemoglobinuria2025 · 1 citations
  4. 4Clinical outcomes of frontline ATG-based immunosuppressive therapy in older patients with aplastic anemia2025
  5. 5Trends and predictors of inpatient mortality in patients with aplastic anemia: A 7-year national inpatient sample analysis2025