Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Platelet decrease and efficacy of platelet-rich plasma return for CAR-T lymphocyte apheresis in low-weight patients

View Full Paper
Ask AI
Bookmark
Share

Authors

SYShunsuke YamamotoYKYuhki KogaKAKoichi Akashi

Discussion

Loading...

Member takes

Overview

Observational analysis shows significant platelet loss during CAR-T lymphocyte apheresis in pediatric patients, highlighting the role of PRP return as a mitigating strategy.

Key Points

  • Platelet counts significantly decreased during lymphocyte apheresis in pediatric acute lymphoblastic leukemia patients, indicating a high risk of thrombocytopenia.
  • Among patients weighing less than 25 kg, the median decrease in platelet counts was 77 × 10⁹/L, associated with processed blood volume per kilogram.
  • Assessment focused on the impact of platelet-rich plasma return, which notably improved median platelet counts post-apheresis by nearly 43 × 10⁹/L.
  • Having body weight and processed blood volume emerged as key risk factors necessitating tailored apheresis protocols for these vulnerable patients.

Cite This Study

Yamamoto et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfdahttps://doi.org/10.1182/blood-2025-7702
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Individualizing apheresis processing volumes using a predictive algorithm: Analysis of the CAR T-cell collection protocol utilized in ACIT001/EXC002, a phase lb/ll trial of decentralized production of CAR T-cells for treatment of relapsed/refractory aggressive NHL and ALL2025
  2. 2Peripheral blast count at apheresis as a risk factor for survival following tisagenlecleucel in children and young adults2025
  3. 3Correlation of T cell fitness of apheresis products with response to CAR T-cell therapy in patients with relapsed or refractory large B-cell lymphoma: A prospective observational study at a single center2025
  4. 4Poor neutrophil recovery following CD19-targeted CAR-T cell therapy predicts inferior outcomes in adult patients with B-cell lymphoma2025
  5. 5TPO-ras for persistent thrombocytopenia following CAR-T therapy in multiple myeloma: A multicenter clinical experience2025