Correlation of T cell fitness of apheresis products with response to CAR T-cell therapy in patients with relapsed or refractory large B-cell lymphoma: A prospective observational study at a single center
Observational study analyzes T cell fitness and response to CAR T-cell therapy in r/r large B-cell lymphoma, suggesting biomarkers for treatment guidance.
Key Points
Enhanced T cell fitness is associated with higher response rates to CAR T-cell therapy, indicating potential for durable remissions.
Memory T cells and naïve T cells are critical biomarkers correlated with therapeutic outcomes in patients undergoing treatment.
Prospective observational analysis at a single center utilized flow cytometry for comprehensive immune profiling of T cell subsets.
Results highlight the importance of pre-treatment T cell composition in optimizing CAR T-cell therapy strategies.