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December 8, 2025Blood

Clinical characteristics and outcomes in patients with SH2B3-mutated erythrocytosis: A retrospective cohort study

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Authors

AMAidan McKeeJHJenny HoBSBekim Sadiković

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Overview

Retrospective cohort study shows low thrombotic risk and mortality in SH2B3-mutated erythrocytosis compared to JAK2-mutated PV.

Key Points

  • Rates of venous thrombosis were low in patients with SH2B3-mutated erythrocytosis, with only one event reported.
  • Median hemoglobin levels were similar across SH2B3-mutated, secondary erythrocytosis, and polycythemia vera groups, averaging around 176 g/L.
  • Data extraction included clinical characteristics and treatments such as phlebotomy and antithrombotic therapy for patients evaluated for erythrocytosis.
  • Limited sample size highlights the need for further research to clarify the clinical implications of SH2B3 mutations in erythrocytosis.

Cite This Study

McKee et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfcehttps://doi.org/10.1182/blood-2025-7317
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The presence of SH2B3 mutations identifies a distinct subtype of myelodysplastic neoplasms2025
  2. 2Application of polycythemia vera guidelines in pediatric patient with erythrocytosis: A case series2025
  3. 3Next-generation sequencing panel for hereditary erythrocytosis identifies genomic variants in over half of adults with otherwise unexplained erythrocytosis2025
  4. 4PO51 | Thrombocythemia associated with a non-canonical JAK2 mutation: a case report2025
  5. 5Clinical characteristics, disease progression, and vascular events in essential thrombocythemia: A single-center cohort study with long-term follow-up.2025