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December 8, 2025Blood

Clinical characteristics, disease progression, and vascular events in essential thrombocythemia: A single-center cohort study with long-term follow-up.

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Authors

LMLourdes M. Mendez

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Overview

Cohort analysis found 12% progressed to acute myeloid leukemia and 44% to secondary myelofibrosis, suggesting high risk in essential thrombocythemia.

Key Points

  • Progression to acute myeloid leukemia occurred in 12% of patients, correlating with genetic markers and treatment options.
  • Among 90 patients, median follow-up reached 15.5 years, with significant rates of transformation noted during this period.
  • Observational analysis focused on long-term clinical outcomes and vascular events in essential thrombocythemia patients.
  • Risk factors, including specific mutations and treatment types, may influence the high transformation rates observed.

Cite This Study

Lourdes M. Mendez (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3e5https://doi.org/10.1182/blood-2025-7322
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