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December 8, 2025Blood

Causes of death in DDX41-mutated myeloid neoplasms: A retrospective study

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Retrospective study reveals infections commonly cause death in myelodysplastic patients, highlighting the need for intervention.

Infections were the cause of death in 70% of myelodysplastic patients, while disease progression was prevalent in acute myeloid leukemia cases.
Survival analysis indicated a median survival of 29 months for deceased DDX41m patients, with a notable distinction in causes of death.
Next generation sequencing was employed to identify pathogenic DDX41 mutations, differentiating between myeloid neoplasms and variants.
This study underscores the need for strategies to mitigate infection-related mortality in patients with DDX41 mutations.

Jevremović et al. (2025) studied this question.

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December 8, 2025Blood

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Authors

Retrospective study reveals infections commonly cause death in myelodysplastic patients, highlighting the need for intervention.

Infections were the cause of death in 70% of myelodysplastic patients, while disease progression was prevalent in acute myeloid leukemia cases.
Survival analysis indicated a median survival of 29 months for deceased DDX41m patients, with a notable distinction in causes of death.
Next generation sequencing was employed to identify pathogenic DDX41 mutations, differentiating between myeloid neoplasms and variants.
This study underscores the need for strategies to mitigate infection-related mortality in patients with DDX41 mutations.

Jevremović et al. (2025) studied this question.

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