Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Single-cell dissection of pathogenic T-cell response to tacrolimus in immune thrombocytopenia

View Full Paper
Ask AI
Bookmark
Share

Authors

LYLiping YangQHQiu-Sha HuangXZXiangyu Zhao

Discussion

Loading...

Member takes

Overview

Observational analysis uncovered the role of tacrolimus on T-cell subpopulations in immune thrombocytopenia, suggesting therapeutic targets for proinflammatory responses.

Key Points

  • Tacrolimus treatment reduces proinflammatory T-cell subsets in patients with immune thrombocytopenia, enhancing platelet counts.
  • Single-cell RNA sequencing revealed significant expression of CXCR3 and other markers in T-cells from patients post-tacrolimus treatment.
  • Analysis of T-cell populations involved methods including single-cell RNA sequencing and CyTOF to assess immune heterogeneity in ITP.
  • Targets identified in T-cell subsets indicate potential focuses for precision therapy in immune thrombocytopenia management.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df26https://doi.org/10.1182/blood-2025-3024
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The JAK1/2 inhibitor baricitinib revealed unique immune biomarkers in multirefractory immune thrombocytopenia patients2025
  2. 2Pre-treatment immune profiling by flow cytometry and single-cell transcriptomics identifies distinct features in B and T cells in rituximab responders and non-responders2025
  3. 3Features of the subpopulation composition and functional activity of peripheral blood lymphocytes and monocytes in patients with primary autoimmune thrombocytopenia2025 · 1 citations
  4. 4Causal relationship between immune cells and idiopathic thrombocytopenic purpura: A bidirectional Mendelian randomization study2025
  5. 5Metabolic reprogramming of megakaryocyte subpopulations in ITP: Implications for TSPO in predicting response to TPO-RA2025 · 1 citations