December 8, 2025BloodOpen Access

Characteristics and clinical course of younger Patients with early lesions in a contemporary cohort of 1240 patients: Low risk features and low risk of complications

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Progression rate to symptomatic disease for patients under 50 was notably low, at just 4% within 5 years.
Among younger patients, 52% were diagnosed with MGUS, 45% with SMM, showing similar biological features compared to older patients.
The study analyzed 1240 patients with asymptomatic monoclonal gammopathies based on IMWG criteria across a median follow-up of 3 years.
Findings highlight the importance of monitoring younger patients diagnosed with low-risk monoclonal gammopathies to minimize anxiety.

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Implication

Analysis of 1240 patients shows low risk of progression in younger individuals with monoclonal gammopathies, indicating a positive long-term prognosis.

Cite This Study

Ntanasis‐Stathopoulos et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236de8e https://doi.org/10.1182/blood-2025-2191

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Implication

Analysis of 1240 patients shows low risk of progression in younger individuals with monoclonal gammopathies, indicating a positive long-term prognosis.

Characteristics and clinical course of younger Patients with early lesions in a contemporary cohort of 1240 patients: Low risk features and low risk of complications

Key Points

Discussion

Implication

Cite This Study

Characteristics and clinical course of younger Patients with early lesions in a contemporary cohort of 1240 patients: Low risk features and low risk of complications

Key Points

Discussion

Implication

Cite This Study

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