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December 8, 2025Blood

Distinct archetypes of clonal dynamics underlie response and resistance to diverse CLL therapies

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Authors

CJConnor JohnsonETEugen TauschSRSandra Robrecht

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Overview

Observational analysis identified 4 distinct archetypes of clonal evolution in CLL patients, indicating varied responses to chemotherapy and targeted therapies.

Key Points

  • Clonal evolution leads to diverse therapeutic responses in chronic lymphocytic leukemia therapies.
  • Four archetypes of clonal dynamics were identified among 107 patients treated with chemotherapy and targeted therapies.
  • Genetic characterization of blood samples revealed significant insight into mutation patterns and clonal behavior during treatment.
  • Markov Chain Monte Carlo modeling highlighted the significance of understanding subclonal dynamics for preventing CLL relapse.

Cite This Study

Johnson et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc71https://doi.org/10.1182/blood-2025-245
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  4. 4Clonal architecture and growth dynamics of ibrutinib-resistant CLL: Oligoclonal BTK/PLCG2 mutations and emerging non-BTK/PLCG2 drivers2025 · 1 citations
  5. 5Resistance Mutations in CLL: Genetic Mechanisms Shaping the Future of Targeted Therapy2025 · 3 citations