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September 11, 2025GenesOpen Access

Resistance Mutations in CLL: Genetic Mechanisms Shaping the Future of Targeted Therapy

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Authors

SSSamantha SekeresELErica N. LamkinEBE.L. Bravo

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Overview

Review shows resistance mutations complicate treatment in chronic lymphocytic leukemia, suggesting new strategies are needed.

Key Points

  • Resistance mutations in CLL complicate treatment, necessitating adaptation of targeted therapies.
  • Targeted therapies like BTK inhibitors and BCL2 inhibitors are effective yet face resistance issues.
  • Novel strategies are being developed, including non-covalent BTK inhibitors and combination therapies.
  • The role of measurable residual disease as a biomarker remains critical for assessing treatment efficacy.

Cite This Study

Sekeres et al. (2025) studied this question.

synapsesocial.com/papers/68d41720713b0b5dfea6331ehttps://doi.org/10.3390/genes16091064
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