Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Targeting nicotinamide salvage pathway is a unique metabolic vulnerability of high-risk MDS stem cells

View Full Paper
Ask AI
Bookmark
Share

Authors

SMSteven MoreiraACA. F. CrookHTH J Terry

Discussion

Loading...

Member takes

Overview

Global proteomics reveals NAMPT as a therapeutic target in high-risk MDS, enhancing azacitidine's efficacy.

Key Points

  • NAMPT inhibition significantly impairs self-renewal and increases cell death in high-risk MDS hematopoietic stem cells.
  • Global proteomics showed altered NAD metabolism and protein synthesis in MDS HSPCs after NAMPT inhibition.
  • Inhibition of NAMPT reduced maximal respiration and spare respiratory capacity in MDS compared to normal HSPCs.
  • Xenograft studies indicated potential for NAMPT as a therapeutic target in high-risk MDS treatment.

Cite This Study

Moreira et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc69https://doi.org/10.1182/blood-2025-232
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NAMPT in macrophages promotes multiple myeloma drug resistance through mitochondrial metabolic reprogramming and modulates immunosuppression via the SIRT1/STAT3/SPP1 axis.2025 · 1 citations
  2. 2Combinatorial targeting of metabolic vulnerabilities in t-cell leukemia through NAMPT inhibition2025
  3. 3Nicotinamide phosphoribosyltransferase in NAD+ metabolism: physiological and pathophysiological implications2025 · 33 citations
  4. 4Nicotinamide N-Methyltransferase in Cardiovascular Diseases: Metabolic Regulator and Emerging Therapeutic Target2025 · 6 citations
  5. 5First-in-human randomized placebo-controlled Phase 1 study of RPT1G, a novel hyperbolic NAMPT inhibitor for use in acute leukemias: Safety, pharmacokinetics, and pharmacodynamics in healthy volunteers2025 · 1 citations