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September 10, 2025BiomoleculesOpen Access

Nicotinamide N-Methyltransferase in Cardiovascular Diseases: Metabolic Regulator and Emerging Therapeutic Target

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Authors

SJSiddiqui JawariaYZYusra ZarlashatMPMárton Philippovich

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Overview

Observational analysis links nicotinamide n-methyltransferase with cardiovascular disease risk factors, suggesting a dual role in health.

Key Points

  • Nicotinamide n-methyltransferase contributes to cardiovascular disease through metabolic regulation and NAD+ depletion.
  • Key evidence shows NNMT upregulation elevates homocysteine levels, activating pro-inflammatory pathways and impairing mitochondrial function.
  • Experimental studies using small-molecule inhibitors demonstrate cardiometabolic benefits, including improved insulin sensitivity and reduced atherosclerosis.
  • Further research is essential to clarify the dual roles of NNMT and translate findings into effective therapeutic strategies.

Cite This Study

Jawaria et al. (2025) studied this question.

synapsesocial.com/papers/68c23b8fb210217d64785ffchttps://doi.org/10.3390/biom15091281
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